What is it?
- Patented low to moderate molecular weight macromolecules that impede dermal penetration.
How does it work?
- These low molecular weight polymers demonstrate an affinity for the epidermis, specifically the stratum corneum, such that they are able to retain any active moieties in the upper layers of the skin.
How is it different?
- Because MacroDerms can be synthesized to exhibit lipophilic, amphiphilic, or hydrophilic characteristics, a wide variety of active moieties can be formulated. More importantly, polymers can be custom synthesized to "fit" a particular application.
An Overview of MacroDerm™ Technology
MacroDerms are low to moderate molecular weight polymers that
can be easily synthesized using proven chemistry. Laboratory
testing has demonstrated that these polymers are physically
and chemically stable and can modulate delivery in a dose-response
fashion.
MacroDerms can be formulated with a broad range of chemical structures and can be custom synthesized to "fit" a particular active moiety. MacroChem believes that the most relevant application of these polymers will be in the areas of cosmetics, personal care products and selected pharmaceuticals.
MacroChem has three issued U.S. patents (No. 5,807,957, No. 5,906,822,
and No. 5,911,980) directed to the chemical composition and use
of these polymers.
Laboratory Studies that Demonstrate the Utility of MacroDerms
Improved Sunscreen. One potential product candidate for MacroDerm™ technology is sunscreen with improved skin retention. Octyl dimethyl PABA is one of the active ingredients in many sunscreens. The data depicted below show that MacroDerm™ can improve the retention of octyl dimethyl PABA in human skin.
Improved Insect Repellant. Another potential product candidate
for MacroDerm™ technology is to improve the persistence of insect
repellant on skin. DEET is one of the active ingredients in many
insect repellants. The data depicted below demonstrates that increasing
concentrations of MacroDerm™ reduces the amount of DEET that is
absorbed through human skin.
